Core Lead
Dr. Rissman is Professor Physiology and Neuroscience and the W.M. Keck Endowed Professor in Medicine. He is the founding Director of the Neuroscience Translational Research Division and the ATRI Biomarker Laboratory and Biorepository. He is the Alzheimer’s Clinical Trials Consortium (ACTC) Biorepository Unit Lead.
The goal of Dr. Rissman’s basic science research is on novel biomarker discovery in Alzheimer’s Disease (AD) and preclinical studies in experimental. A major focus of his lab in AD biomarkers is on the utility and mechanistic underpinnings of neuronal exosomes and his group has published manuscripts demonstrating the ability of tau and abeta in neuronal exosomes to predict conversion from MCI to AD. The lab also investigates the contribution of stress and changes in stress signaling intermediates in Alzheimer’s disease neuropathology. Using transgenic mice and in vivo pharmacology, experiments are focused on identifying the role of corticotropin-releasing factor (CRF) receptors in beta-amyloid deposition, tau phosphorylation and behavioral and synaptic changes.
1501 San Pablo St., Health Sciences Campus Los Angeles CA 90033