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The Administrative Core is responsible for the scientific leadership and stewardship of Center resources as a whole. Each year the Administrative Core brings together investigators for symposia [Link to Zilkha Symposium] and workshops. The Administrative Core also fosters the development and selection of pilot projects.

Leadership team

Helena Chui MD., Director

During the past 30 years, Dr. Chui’s research interests have focused on aging, Alzheimer disease, and vascular contributions to cognitive impairment in late life. For the past 20 years, she served as principal investigator of the Aging Brain Program Project, a multi-institutional longitudinal study to characterize interactions between vascular and Alzheimer disease, using state-of-the-art clinical-imaging-pathological correlations. Her team is particularly interested in non-occlusive pathways leading from vascular risk factors to vascular brain injury or AD pathology. Recently, they showed that low HDL and high HDL-C are independently correlated with β-amyloid deposition in the brain and that HDL-C may have a protective effect against brain atrophy. During the past 10 years, Dr. Chui has served Director of the Alzheimer Disease Research Center and Chair of the Department of Neurology at USC.

Arthur Toga, PhD., Co-Director

Dr. Toga has a career-long record of funding and publication in the analysis, modeling and atlasing of images obtained from many species including humans. Dr. Toga directs several national and international collaborative studies that involve multisite acquisition of data, coordination of analysis, and dissemination of data and results. The USC Institute for Neuroimaging and Informatics (INI) and his laboratory coordinates neuroimage analysis and related informatics activities with national and international collaborators and, as such, is a worldwide resource by virtue of these distributive activities. Dr. Toga has experience and expertise in local and wide area computer networks, data transmission, storage and archiving as well as data compression and scientific visualization.

Berislav Zlokovic, MD, PhD., Co-Director

Dr. Zlokovic has a long standing interest in understanding the role of cerebral blood vessels and blood-brain barrier in the pathogenesis and treatment of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and stroke. Using experimental models of Alzheimer’s disease and studying human brain, his research team has shown that disruption of cellular cross-talk within the neurovascular unit can initiate neuronal dysfunction and injury, degeneration and loss, as well as accumulation Aβ and tau pathology. His lab has been working on developing new biomarkers of cell and system specific injury within the neurovascular unit; and new imaging biomarkers of neurovascular function in humans (DCE-MRI test) to narrow the gap between preclinical translational studies and clinical studies.