Alzheimer Disease Research Center (ADRC)
Resources for Investigators - Research Themes

Resources for Investigators

Research Themes

Research Themes
ADRC Organization (6 Cores)

Vascular Cohort Study (VCS) - 2 Projects
Pilot Projects
Request to use ADRC Resources

Request to Use The Modified Mini-Mental State (3MS) Test 

Request to Use The ADCS-CGIC and CIBIC+ 

Nutrition Program for Brain Health - Manuals in Spanish and English

 


Research Themes

The USC ADRC focuses on mild cognitive changes related to aging, Alzheimer disease (AD) and cerebrovascular disease (CVD) in multi-ethnic communities. The USC ADRC has three overarching goals: 1) elucidate vascular contributions to Alzheimer’s disease (AD); 2) catalyze local research in AD at USC (especially Phase I/Phase II clinical trials); and 3) contribute expertise in vascular disease and imaging to national collaborative initiatives.  The USC ADRC is an integral part of the national Alzheimer Disease Center (ADC) network, working closely with the National Alzheimer Coordinating Center (NACC), Alzheimer Cooperative Studies (ADCS), the Alzheimer Disease Genetics Consortium (ADGC), and Alzheimer Disease Neuroimaging Intiative (ADNI).

 ADRC Organization (6 Cores)

The Administrative Core (Chui & Zlokovic) is responsible for the overall scientific direction of the center and the coordination of 5 other service cores, 2 research projects, and 2 pilot projects per year.  Project 1 (Zlokovic) and Project 2 (Braskie) share a complementary focus on the role of Neurovascular and Metabolic Factors on AD pathogenesis, thereby giving scientific cohesiveness to the Center as a whole.

The Clinical core (Schneider), assisted by the Outreach core (Williams), will constitute and follow a new Vascular Cohort Study (n-180) to support Projects 1 and 2, and will refer well-characterized participants to clinical trials, the brain donation (autopsy) program, and other research projects.  The Imaging core (Law, Toga, Thompson) offers innovations in imaging the integrity of the blood brain barrier (DCE-MRI), white matter fiber tracts (DTI-MRI), and functional connectivity (fMRI). The Neuropathology core (Miller), which characterizes and shares brain tissues and biospecimens, will provide a comprehensive panel of CSF biomarkers.  The Data core (Toga) will make available on line and without embargo, the imaging, biomarker, and clinical-pathological data from ADRC participants. 

Vascular Cohort Study (VCS)

Epidemiologic studies have observed that vascular risk factors (VRF), such as hypertension and diabetes mellitus, are linked to a 1.5 to 2-fold increased risk of incident AD. With the development of amyloid-ligands for PET imaging and CSF biomarkers for β-amyloid and p-tau, it is now possible to test in vivo whether VRF are specifically linked to AD biomarkers.   In Project 1, we hypothesize that the association between hypertension and β-amyloid is mediated by arterial stiffness, as assessed by perfusion MRI.  In project 2, we hypothesize that increased insulin, decreased IGF-1, and decreased cholesterol efflux capacity will correlate with CSF β-amyloid. These projects will be supported by a new longitudinal Vascular Cohort Study, designed to elucidate the temporal sequence of events, leading to, accelerating, or decelerating amyloidopathy and neuronal degeneration (tau).

ADRC Pilot Projects

Every year the ADRC funds 1-2 pilot projects. The REQUEST FOR PROPOSALS (RFP) is sent out in August and September of each project period by email, and it invites interested clinical and basic science investigators to submit letters of intent for one year pilot research projects.

Learn more about our Pilot Projects.

BUDGET 

Investigators may request direct costs up to $30,000 per year for pilot projects. Duration of pilot projects is for 1 year. Non -USC investigators and sites must identify a USC collaborator and submit proposal as a subcontract to USC.

Investigators are encouraged to use ADRC resources, including Cores and established subject cohorts. 

Learn more about our Resources

To Collaborate

To discuss collaboration, please contact the Center administrator, Elena Taylor-Munoz at 323-442-7674