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PROJECT 2: METABOLIC FACTORS AND ALZHEIMER DISEASE

Meredith Braskie, PhD, Leader

Dr. Braskie has focused her research efforts on Alzheimer disease risk factors and disease progression, using multi-modal brain imaging, including functional and structural MRI, diffusion tensor imaging, resting state fMRI, and positron emission tomography. Previous publications have focused on clusterin and white matter integrity, thickness of hippocampal area subregions, and amyloid imaging. The goal of project 2 is to evaluate how two mechanisms that link type 2 diabetes mellitus: insulin signaling and cholesterol efflux may contribute to brain deficits implicated in Alzheimer’s disease (AD).

Hussein Yassine, MD

Dr. Yassine is clinical and research lipidologist who is interested in how lipids relate to metabolic diseases. As a research scientist, he is interested in examining the role of HDL function in chronic diseases. He obtained the National Lipid Association Board certification and a career development award from NIH to study the role of proteins attached to HDL on HDL function. In project 2, he will determine if HDL cholesterol efflux capacity is an important mechanism to protect against amyloid deposition in Alzheimer’s disease.