Alzheimer Disease Research Center (ADRC)
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PhytoSERM Study

Management of Menopause and Age Associated Memory Decline


This clinical trial is sponsored by the NIH and Keck School of Medicine of USC. We are testing a soy based dietary supplement in healthy peri- and post-menopausal women who have mild hot flashes and memory complaints. 
The purpose of this double-blind and placebo-controlled 14-week study is to find the best dose, safety and tolerance of phytoSERMs in healthy peri- and post-menopausal women who are experiencing HOT FLASHES and/or a complaint about their MEMORY. We hope to learn whether phytoSERMs are a possible non-drug treatment for these problems and might have potential to prevent age-related cognitive decline...

Volunteers should be women between 45 and 58 years of age, have a vasomotor-related symptom (hot flashes) and/or a memory complaint, should not be taking hormone replacement therapy, and be in good health.

This study is being conducted at the Memory and Aging Center clinics in the Health and Science Campus of USC (Los Angeles, near Pasadena and Alhambra).

Investigators: Lon Schneider, MD; Roberta Diaz Brinton, PhD; Wendy Mack, PhD; Liqin Zhao, PhD

Study Contact:
Gerson Hernandez, MD; (323) 442-7608;
Nadine Diaz, MSW; (323) 442-7603;

Additional Basic Information


May 2012


This study is sponsored by the National Institutes of Health (NIH) and the Keck School of Medicine of USC.


PhytoSERM is a dietary supplement composed of a combination of selected phytoestrogens, which are a group of naturally occurring compounds that are commonly found in soy.